Kmt5c Gene Summary [Mouse]
Enables histone H4K20 methyltransferase activity and histone binding activity. Involved in positive regulation of isotype switching. Located in condensed chromosome, centromeric region. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kmt5c |
| Official Name | lysine methyltransferase 5C [Source:MGI Symbol;Acc:MGI:2385262] |
| Ensembl ID | ENSMUSG00000059851 |
| Bio databases IDs | |
| Aliases | lysine methyltransferase 5C |
| Synonyms | lysine methyltransferase 5C, SUV420H2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kmt5c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone lysine N-methyltransferase activity (H4-K20 specific)
- histone binding
- histone methyltransferase
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- binding protein
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- chromatin binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- breast adenocarcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
role in cell
- binding in
- proliferation
- expression in
- growth
- binding
- cell cycle progression
- cohesion
- sensitivity
- scattering
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kmt5c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- chromatin remodeling
- positive regulation of isotype switching
- positive regulation of double-strand break repair via nonhomologous end joining
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- condensed chromosome, centromeric region
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- metal ion binding
- chromatin binding
- histone methyltransferase activity (H4-K20 specific)