Ccnl1 Gene Summary [Mouse]

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nuclear speck. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex and transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in head. Orthologous to human CCNL1 (cyclin L1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Nonsense Mediated Decay
Official Symbol
Ccnl1
Official Name
cyclin L1 [Source:MGI Symbol;Acc:MGI:1922664]
Ensembl ID
ENSMUSG00000027829
Bio databases IDs NCBI: 56706 Ensembl: ENSMUSG00000027829
Aliases cyclin L1
Synonyms 2610030E23Rik, ANIA6A, BM-001, Ccnl, CYCLIN L, cyclin L1, LOC100909712, PRO1073
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cyclin box fold superfamily
  • Cyclin, N-terminal domain
  • protein binding
  • domain present in cyclins, TFIIB and Retinoblastoma

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
regulated by
  • lipopolysaccharide
  • TP53
  • U0126
  • PDGF-BB
  • RB1
  • gentamicin
  • KLF6
  • TBX2
  • niacinamide
  • HuH7 cells
disease
  • breast cancer
  • idiopathic pulmonary fibrosis
role in cell
  • survival
  • mitosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm
  • nuclear speckles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnl1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of RNA splicing
  • regulation of apoptotic process
  • regulation of cell cycle
  • regulation of centrosome cycle
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nuclear speck
  • cyclin-dependent protein kinase holoenzyme complex

Molecular Function

What the gene product does at the molecular level
  • cyclin-dependent protein kinase regulator activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

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