Tub Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity and intraciliary transport particle A binding activity. Acts upstream of or within several processes, including phagocytosis, recognition; photoreceptor cell maintenance; and protein localization to non-motile cilium. Located in cytosol and extracellular region. Is expressed in several structures, including central nervous system; endocrine gland; musculature; peripheral nervous system; and sensory organ. Used to study obesity. Orthologous to human TUB (TUB bipartite transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tub |
| Official Name | tubby bipartite transcription factor [Source:MGI Symbol;Acc:MGI:2651573] |
| Ensembl ID | ENSMUSG00000031028 |
| Bio databases IDs | |
| Aliases | tubby bipartite transcription factor |
| Synonyms | rd5, RDOB, TUB bipartite transcription factor, TUBBY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tub often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tub family
- Tubby N-terminal
- transcription regulator
- binding protein
- G-protein-coupled receptor binding
- protein binding
Pathways
Biological processes and signaling networks where the Tub gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early missed abortion
- retinal dystrophy
- lung adenocarcinoma
- lung adenocarcinoma formation
- weight gain
- age-related hearing loss
- hearing loss
- adult-onset obesity
- increased body mass index
- obesity
role in cell
- function
- formation
- apoptosis
- number
- degeneration
- phagocytosis by
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Extracellular Space
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tub gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- phagocytosis, recognition
- intraflagellar transport
- retina development in camera-type eye
- photoreceptor cell maintenance
- regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding