Scrt2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of neuron migration. Located in nucleus. Is expressed in future hindbrain; nervous system; and retina. Orthologous to human SCRT2 (scratch family transcriptional repressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scrt2 |
| Official Name | scratch family zinc finger 2 [Source:MGI Symbol;Acc:MGI:2139287] |
| Ensembl ID | ENSMUSG00000060257 |
| Bio databases IDs | |
| Aliases | scratch family zinc finger 2 |
| Synonyms | AW060659, RGD1564796, scratch family transcriptional repressor 2, scratch family zinc finger 2, ZNF898B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scrt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- MYCN amplification positive aggressive neuroblastoma
- neuroblastoma formation
regulated by
- Streptococcus pneumoniae TIGR4
- dopamine
- cantharidin
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scrt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity