S100a13 Gene Summary [Mouse]
Predicted to enable several functions, including RAGE receptor binding activity; fibroblast growth factor binding activity; and metal ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of interleukin-1 alpha production; and regulation of cell shape. Located in extracellular space. Is expressed in brown fat and heart. Orthologous to human S100A13 (S100 calcium binding protein A13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a13 |
| Official Name | S100 calcium binding protein A13 [Source:MGI Symbol;Acc:MGI:109581] |
| Ensembl ID | ENSMUSG00000042312 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A13 |
| Synonyms | RP1 178F155, S100A1, S100 calcium binding protein A13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S100a13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- S-100/ICaBP type calcium binding domain
- fibroblast growth factor binding
- zinc ion binding
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- recurrent implantation failure
- amyotrophic lateral sclerosis
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S100a13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of interleukin-1 alpha production
- mast cell degranulation
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- extracellular region
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein homodimerization activity
- protein binding
- copper ion binding
- calcium ion binding
- calcium-dependent protein binding
- fibroblast growth factor binding
- lipid binding
- RAGE receptor binding