Pwwp2b Gene Summary [Mouse]
Predicted to enable NuRD complex binding activity. Involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Located in nucleus. Orthologous to human PWWP2B (PWWP domain containing 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pwwp2b |
| Official Name | PWWP domain containing 2B [Source:MGI Symbol;Acc:MGI:2142008] |
| Ensembl ID | ENSMUSG00000060260 |
| Bio databases IDs | |
| Aliases | PWWP domain containing 2B |
| Synonyms | bA432J24.1, D7Ertd517e, D930023J19Rik, pp8607, PWWP2, PWWP domain containing 2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pwwp2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pwwp2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding