Prkdc Gene Summary [Mouse]
Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including regulation of hematopoietic stem cell differentiation; regulation of hemopoiesis; and regulation of protein metabolic process. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and hemopoiesis. Located in nucleus. Is expressed in several structures, including central nervous system; liver; neural retina; and thymus primordium. Used to study Duchenne muscular dystrophy; severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Prkdc |
| Official Name | protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779] |
| Ensembl ID | ENSMUSG00000022672 |
| Bio databases IDs | |
| Aliases | protein kinase, DNA activated, catalytic polypeptide |
| Synonyms | DNA-DEPENDENT protein KINASE, DNAPDcs, DNAPK, DNA-PKC, DNA-PKcs, DNPK1, DOXNPH, dxnph, HYRC, HYRC1, IMD26, p350, p460, Prkdc predicted, protein kinase, DNA activated, catalytic polypeptide, protein kinase, DNA-activated, catalytic subunit, scid, slip, XRCC7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkdc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-dependent protein kinase
- protein serine/threonine kinase
- protein kinase
- Phosphatidylinositol 3- and 4-kinase
- DNA-dependent protein kinase catalytic subunit, CC1/2
- enzyme binding
- transcription factor binding
- leucine zipper domain
- protein domain specific binding
- protein binding
- autophosphorylation site
- enzyme
- FATC domain
- kinase
- kinase domain
- DNA-PKcs, N-terminal
- FAT domain
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- DNA-PKcs, CC5
- double-stranded DNA binding
- snoRNA binding
- DNA-dependent protein kinase catalytic subunit, CC3
Pathways
Biological processes and signaling networks where the Prkdc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- cancer
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- dysplasia
- breast cancer metastatic to brain
phenotypes
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin concentration
- decreased prepulse inhibition
- increased circulating phosphate level
- increased eosinophil cell number
- increased monocyte cell number
- increased neutrophil cell number
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal CD4-positive T cell differentiation
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal DNA repair
- abnormal NK cell physiology
- abnormal Peyer's patch morphology
- abnormal T cell differentiation
- abnormal T cell number
- abnormal T cell receptor V(D)J recombination
- abnormal T cell receptor alpha chain V-J recombination
- abnormal T cell receptor beta chain V(D)J recombination
- abnormal T cell receptor delta chain V(D)J recombination
- abnormal circulating phosphate level
- abnormal class switch recombination
- abnormal colon morphology
- abnormal complement pathway
- abnormal hematopoietic stem cell physiology
- abnormal humoral immune response
- abnormal immune system physiology
- abnormal immunoglobulin V(D)J recombination
- abnormal immunoglobulin heavy chain V(D)J recombination
- abnormal immunoglobulin light chain V-J recombination
- abnormal intestinal epithelium morphology
- abnormal kidney morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal leukocyte cell number
- abnormal level of surface class II molecules
- abnormal lymph node B cell domain morphology
- abnormal lymph node morphology
- abnormal lymphocyte cell number
- abnormal lymphocyte morphology
- abnormal monocyte cell number
- abnormal neutrophil cell number
- abnormal prepulse inhibition
- abnormal response to transplant
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- abnormal thymus corticomedullary boundary morphology
- abnormal thymus lobule morphology
- abnormal thymus morphology
- absent B cells
- absent Peyer's patches
- absent T cells
- absent mature B cells
- absent pre-B cells
- absent thymus cortex
- absent thymus corticomedullary boundary
- arrested B cell differentiation
- arrested T cell differentiation
- cecum inflammation
- colitis
- decreased B cell number
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased B-1a cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased IgG level
- decreased IgM level
- decreased NK T cell number
- decreased NK cell number
- decreased T cell number
- decreased T cell proliferation
- decreased alpha-beta T cell number
- decreased bone marrow cell number
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased effector memory CD4-positive alpha-beta T cell number
- decreased erythrocyte cell number
- decreased gamma-delta T cell number
- decreased granulocyte number
- decreased hematopoietic stem cell number
- decreased immunoglobulin level
- decreased level of surface class I molecules
- decreased macrophage cell number
- decreased mature B cell number
- decreased pre-B cell number
- decreased single-positive T cell number
- decreased spleen white pulp amount
- decreased thymocyte apoptosis
- decreased thymocyte number
- diarrhea
- enhanced humoral immune response
- enlarged mesenteric lymph nodes
- glomerulosclerosis
- hyperpigmentation
- impaired complement classical pathway
- impaired humoral immune response
- impaired natural killer cell mediated cytotoxicity
- increased B cell number
- increased B-1b cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgM level
- increased NK cell number
- increased T cell derived lymphoma incidence
- increased T cell number
- increased alpha-beta T cell number
- increased body weight
- increased bone marrow cell number
- increased cellular sensitivity to X-ray irradiation
- increased cellular sensitivity to alkylating agents
- increased cellular sensitivity to gamma-irradiation
- increased cellular sensitivity to ionizing radiation
- increased cellular sensitivity to ultraviolet irradiation
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased circulating glucose level
- increased double-negative T cell number
- increased double-positive T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased granulocyte number
- increased length of allograft survival
- increased macrophage cell number
- increased mean corpuscular volume
- increased mortality induced by gamma-irradiation
- increased mortality induced by ionizing radiation
- increased physiological sensitivity to xenobiotic
- increased plasma cell number
- increased plasmacytoid dendritic cell number
- increased sensitivity to induced cell death
- increased small intestinal crypt cell apoptosis
- increased urine protein level
- interstitial pneumonia
- intestine polyps
- liver inflammation
- lymph node hyperplasia
- lymph node hypoplasia
- lymphoid hypoplasia
- myeloid hyperplasia
- pallor
- pancytopenia
- postnatal lethality incomplete penetrance
- premature death
- preneoplasia
- salivary gland inflammation
- slow postnatal weight gain
- small Peyer's patches
- small lymph nodes
- small lymphoid organs
- small spleen
- small thymus
- spleen hypoplasia
- stomach inflammation
- thrombocytopenia
- thymus cysts
- thymus hypoplasia
role in cell
- cell death
- apoptosis
- fragmentation
- survival
- production in
- expression in
- phosphorylation in
- activation in
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- low-density microsomal fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- pre-ribosome
- Cytoplasm
- Plasma Membrane
- centrosome
- midbody
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear scaffolds
- membrane rafts
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkdc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- positive regulation of translation
- positive regulation of lymphocyte differentiation
- T cell lineage commitment
- regulation of circadian rhythm
- double-strand break repair via nonhomologous end joining
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- positive regulation of erythrocyte differentiation
- double-strand break repair
- cellular response to insulin stimulus
- regulation of smooth muscle cell proliferation
- heart development
- chromatin remodeling
- maturation of 5.8S rRNA
- activation of innate immune response
- telomere capping
- response to gamma radiation
- regulation of epithelial cell proliferation
- germ cell programmed cell death
- mitotic cell cycle G1/S transition DNA damage checkpoint
- T cell differentiation in thymus
- small-subunit processome assembly
- T cell receptor V(D)J recombination
- immunoglobulin V(D)J recombination
- telomere maintenance
- DNA damage response, signal transduction resulting in induction of apoptosis
- brain development
- response to DNA damage stimulus
- protein destabilization
- B cell lineage commitment
- rhythmic process
- immature B cell differentiation
- somitogenesis
- pro-B cell differentiation
- negative regulation of apoptotic process
- innate immune response
- negative regulation of protein phosphorylation
- positive regulation of apoptotic process
- positive regulation of double-strand break repair via nonhomologous end joining
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- DNA-dependent protein kinase complex
- nonhomologous end joining complex
- nucleolus
- chromatin
- nucleoplasm
- transcription factor complex
- chromosome, telomeric region
- nucleus
- DNA-dependent protein kinase-DNA ligase 4 complex
- membrane
- protein-DNA complex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- DNA-dependent protein kinase activity
- ATP binding
- protein domain specific binding
- protein binding
- RNA binding
- double-stranded DNA binding
- U3 snoRNA binding
- protein kinase activity
- histone kinase activity (H2A-S139 specific)
- protein serine/threonine kinase activity
- enzyme binding