Rbbp4 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly; chromatin remodeling; and regulation of DNA-templated transcription. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina nuclear layer. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbbp4 |
| Official Name | retinoblastoma binding protein 4, chromatin remodeling factor [Source:MGI Symbol;Acc:MGI:1194912] |
| Ensembl ID | ENSMUSG00000057236 |
| Bio databases IDs | |
| Aliases | retinoblastoma binding protein 4, chromatin remodeling factor |
| Synonyms | CAF1 P48, CAF1/p48, CAF-1 subunit C, CAF-I 48 kDa subunit, lin-53, LOC681419, LOC685491, mRbAp48, NURF55, p46/48, RBAP48, Rb-associated protein p48, RB binding protein 4, chromatin remodeling factor, retinoblastoma binding protein 4, chromatin remodeling factor, YQ51D06 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histone-binding protein RBBP4 or subunit C of CAF1 complex
- histone binding
- WD40 repeats
- double-stranded DNA binding
- nucleic acid binding
- WD domain, G-beta repeat
- histone deacetylase binding
- WD40
- enzyme
- protein binding
- sequence-specific DNA binding
- DNA dependent ATPase
Pathways
Biological processes and signaling networks where the Rbbp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- mucoepidermoid carcinoma
role in cell
- apoptosis
- proliferation
- migration
- survival
- quantity
- outgrowth
- size
- formation
- processing in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- insoluble fractions
- cytosol
- nucleoplasm
- telomeres
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell fate specification
- DNA replication
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- brain development
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- CAF-1 complex
- ESC/E(Z) complex
- histone deacetylase complex
- chromatin
- nucleoplasm
- chromosome, telomeric region
- nucleus
- NuRD complex
- cytosol
- macromolecular complex
- NURF complex
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- DNA-dependent ATPase activity
- protein binding
- histone deacetylase binding
- histone binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- nucleosomal DNA binding