Hnrnpc Gene Summary [Mouse]

Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of nucleobase-containing compound metabolic process. Located in pronucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 74. Orthologous to several human genes including HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Hnrnpc
Official Name
heterogeneous nuclear ribonucleoprotein C [Source:MGI Symbol;Acc:MGI:107795]
Ensembl ID
ENSMUSG00000060373
Bio databases IDs NCBI: 15381 Ensembl: ENSMUSG00000060373
Aliases heterogeneous nuclear ribonucleoprotein C
Synonyms C1, C2, D14Wsu171e, Heterogeneous nuclear ribonucleoprotein C, HNRNP, hnRNPC1, Hnrnp C1/C2, hnRNPC2, HNRPC, Hnrpc1, Hnrpc2, LOC100911576, MRD74, REBIP, SNRPC
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • mRNA binding
  • protein binding activity, bridging
  • enzyme inhibitor activity
  • nuclear localization sequence
  • enzyme binding
  • protein domain specific binding
  • protein binding
  • identical protein binding
  • acidic domain
  • proline rich domain
  • RNA binding
  • bZIP domain
  • poly(U) binding protein
  • mRNA 3' UTR binding
  • ribonucleoprotein binding
  • RNA-binding domain

Pathways

Biological processes and signaling networks where the Hnrnpc gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colorectal cancer
  • glioblastoma
  • hepatocellular carcinoma
  • epithelial cancer
  • autosomal dominant intellectual developmental disorder type 74
  • vitamin D-resistant rickets
  • organismal death
  • liver cancer
  • metastasis
  • pulmonary hypertensive arterial disease
regulated by
regulates
role in cell
  • expression in
  • apoptosis
  • migration
  • transcription in
  • binding in
  • production in
  • cell viability
  • proliferation
  • growth
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • pH resistant lipid raft fraction
  • catalytic step 2 spliceosome
  • Cytoplasm
  • actin cytoskeleton
  • ribosome
  • cytosol
  • spliceosomes
  • nucleoplasm
  • nucleoli
  • interchromatin granule clusters
  • pronucleus
  • chromatin
  • paraspeckle-like structures

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpc gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • 3'-UTR-mediated mRNA stabilization
  • RNA splicing
  • chromatin remodeling
  • osteoblast differentiation
  • negative regulation of telomere maintenance via telomerase
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • spliceosomal complex
  • extracellular region
  • telomerase holoenzyme complex
  • chromatin
  • nucleoplasm
  • nucleus
  • extracellular vesicular exosome
  • catalytic step 2 spliceosome
  • membrane
  • actin cytoskeleton
  • cytosol
  • macromolecular complex

Molecular Function

What the gene product does at the molecular level
  • identical protein binding
  • protein binding
  • RNA binding
  • telomeric RNA binding
  • nucleosomal DNA binding
  • poly(U) RNA binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.