Rnf14 Gene Summary [Mouse]
Predicted to enable nuclear androgen receptor binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K6-linked ubiquitination; protein-RNA covalent cross-linking repair; and regulation of signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; genitourinary system; sensory organ; and trigeminal nerve. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rnf14 |
| Official Name | ring finger protein 14 [Source:MGI Symbol;Acc:MGI:1929668] |
| Ensembl ID | ENSMUSG00000060450 |
| Bio databases IDs | |
| Aliases | ring finger protein 14 |
| Synonyms | 2310075C09Rik, 2610005D23Rik, ARA54, D18Ertd188e, D7Bwg0165e, HFB30, HRIHFB2038, ring finger protein 14, TRIAD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- IBR domain, a half RING-finger domain
- transcription co-activator
- fxxlf motif
- ubiquitin protein ligase activity
- androgen receptor binding
- BRcat_Rcat_RBR
- Ring finger domain
- protein binding
- ubiquitin-like protein transferase activity
- RWD, DRWD, and ELF domain family
- In Between Ring fingers
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- RWD domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- amyotrophic lateral sclerosis
- organismal death
- systemic juvenile idiopathic arthritis
role in cell
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein polyubiquitination
- regulation of transcription, DNA-dependent
- regulation of androgen receptor signaling pathway
- ubiquitin-dependent protein catabolic process
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- rescue of stalled ribosome
- regulation of canonical Wnt receptor signaling pathway
- androgen receptor signaling pathway
- protein K6-linked ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding
- transcription coactivator activity
- androgen receptor binding
- small conjugating protein ligase activity