RNF14 Gene Summary [Human]
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | RNF14 |
| Official Name | ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058] |
| Ensembl ID | ENSG00000013561 |
| Bio databases IDs | |
| Aliases | ring finger protein 14 |
| Synonyms | 2310075C09Rik, 2610005D23Rik, ARA54, D18Ertd188e, D7Bwg0165e, HFB30, HRIHFB2038, ring finger protein 14, TRIAD2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- IBR domain, a half RING-finger domain
- transcription co-activator
- fxxlf motif
- ubiquitin protein ligase activity
- androgen receptor binding
- BRcat_Rcat_RBR
- Ring finger domain
- protein binding
- ubiquitin-like protein transferase activity
- RWD, DRWD, and ELF domain family
- In Between Ring fingers
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- RWD domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- amyotrophic lateral sclerosis
- organismal death
- systemic juvenile idiopathic arthritis
role in cell
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein polyubiquitination
- regulation of transcription, DNA-dependent
- regulation of androgen receptor signaling pathway
- ubiquitin-dependent protein catabolic process
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- rescue of stalled ribosome
- regulation of canonical Wnt receptor signaling pathway
- androgen receptor signaling pathway
- protein K6-linked ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding
- transcription coactivator activity
- androgen receptor binding
- small conjugating protein ligase activity