Atp8b2 Gene Summary [Mouse]
Predicted to enable phosphatidylcholine flippase activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including central nervous system; limb; seminiferous cord; sensory organ; and skeleton. Orthologous to human ATP8B2 (ATPase phospholipid transporting 8B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp8b2 |
| Official Name | ATPase, class I, type 8B, member 2 [Source:MGI Symbol;Acc:MGI:1859660] |
| Ensembl ID | ENSMUSG00000060671 |
| Bio databases IDs | |
| Aliases | ATPase, class I, type 8B, member 2 |
| Synonyms | ATPase, class I, type 8B, member 2, ATPase phospholipid transporting 8B2, ATPID, Id, LOC100364800, LOC684802 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp8b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid transporter
- Mg2+-ATPase
- Phospholipid-translocating ATPase N-terminal
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- HAD-superfamily hydrolase, subfamily IIB
- phosphatidylcholine transporter
- phospholipid-translocating P-type ATPase, flippase
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Cation transporting ATPase, C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chordoma
- bone cancer
- preeclampsia
- juvenile rheumatoid arthritis
regulates
- ion
- ATP5F1C
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp8b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid translocation
- ion transmembrane transport
- Golgi organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- trans-Golgi network
- cytosol
- Golgi apparatus
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding