Cxcr4 Gene Summary [Mouse]
Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including CXCL12-activated CXCR4 signaling pathway; circulatory system development; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome 1; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcr4 |
| Official Name | chemokine (C-X-C motif) receptor 4 [Source:MGI Symbol;Acc:MGI:109563] |
| Ensembl ID | ENSMUSG00000045382 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) receptor 4 |
| Synonyms | b2b220Clo, CD184, CHEMOKINE CXC4 receptor, CHEMOKINE receptor 4, Cmkar4, C-X-C motif chemokine receptor 4, D2S201E, FB22, FUSIN, HM89, HSY3RR, LAP-3, LCR1, LESTR, LOC100047410, NPY3R, NPYR, NPYRL, NPYY3R, PB-CKR, PBSF/SDF-1, Sdf1r, WHIM, WHIMS, WHIMS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- ubiquitin protein ligase binding
- Cholecystokinin A receptor, N-terminal
- intracellular loop
- DRY motif
- viral receptor
- ubiquitin binding
- CXCR4 Chemokine receptor N terminal
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- C-C chemokine receptor
- myosin binding
- C-X-C chemokine receptor
- binding protein
- C-C chemokine binding
- actin binding
- transmembrane domain
- intracellular domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Cxcr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Axonal Guidance Signaling
- Chemokine Signaling
- CXCR4 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Induction of Apoptosis by HIV1
- Leukocyte Extravasation Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic breast cancer
- leukopenia
- gastric cancer
- pulmonary hypertension
- epithelial neoplasia
- cancer
- infection
- neutropenia
- plasma cell myeloma
- obesity
role in cell
- expression in
- number
- extension
- phosphorylation in
- accumulation in
- activation in
- quantity
- mobilization in
- formation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- GM1-enriched lipid raft
- glial endfeet
- intracellular compartment
- cholesterol-poor microdomain
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- somatodendritic region
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- lysosome
- intercellular junctions
- cytosol
- apical cell surfaces
- plasma membrane extracellular face
- microdomains
- caveolae
- nuclear foci
- growth cone
- neurites
- early endosomes
- late endosomes
- cytoplasmic vesicles
- membrane rafts
- cell membrane leading edge
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- endothelial tube morphogenesis
- regulation of programmed cell death
- telencephalon cell migration
- endothelial cell differentiation
- neurogenesis
- epithelial cell development
- cardiac muscle contraction
- response to virus
- cell chemotaxis
- positive regulation of oligodendrocyte differentiation
- inflammatory response
- neuron migration
- response to hypoxia
- immune response
- regulation of viral reproduction
- apoptotic process
- regulation of calcium ion transport
- calcium-mediated signaling
- cellular response to organic nitrogen
- G-protein coupled receptor signaling pathway
- positive regulation of vascular wound healing
- neuron recognition
- CXCL12-activated CXCR4 signaling pathway
- brain development
- myelin maintenance
- elevation of cytosolic calcium ion concentration
- positive regulation of macrophage migration inhibitory factor signaling pathway
- dendritic cell chemotaxis
- cellular response to xenobiotic stimulus
- cellular response to cytokine stimulus
- detection of mechanical stimulus involved in sensory perception of pain
- response to activity
- regulation of cell adhesion
- regulation of chemotaxis
- detection of temperature stimulus involved in sensory perception of pain
- positive regulation of chemotaxis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell leading edge
- late endosome
- external side of plasma membrane
- plasma membrane
- lysosome
- cell surface
- early endosome
- extracellular vesicular exosome
- anchoring junction
- cytoplasm
- cytoplasmic vesicle
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- C-X-C motif chemokine 12 receptor activity
- coreceptor activity
- small molecule binding
- G-protein coupled receptor activity
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- actin binding
- C-C chemokine receptor activity
- C-X-C chemokine receptor activity
- viral receptor activity
- myosin light chain binding