Arhgap22 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction and regulation of postsynapse organization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap22 |
| Official Name | Rho GTPase activating protein 22 [Source:MGI Symbol;Acc:MGI:2443418] |
| Ensembl ID | ENSMUSG00000063506 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 22 |
| Synonyms | B230341L19RIK, LOC101930357, P68RACGAP, RHOGAP2, RHOGAP22, Rho GTPase activating protein 22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- PH domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Pathways
Biological processes and signaling networks where the Arhgap22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- angiogenesis
- signal transduction
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity