Plcd3 Gene Summary [Mouse]

Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Acts upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Plcd3
Official Name
phospholipase C, delta 3 [Source:MGI Symbol;Acc:MGI:107451]
Ensembl ID
ENSMUSG00000020937
Bio databases IDs NCBI: 72469 Ensembl: ENSMUSG00000020937
Aliases phospholipase C, delta 3
Synonyms 2610205J15RIK, mKIAA1964, phospholipase C delta 3, phospholipase C, delta 3, phospholipase C δ 3, phospholipase C, δ 3, PLC-delta-3, PLC-δ-3
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Phosphatidylinositol-specific phospholipase C, Y domain
  • enzyme
  • Pleckstrin homology-like domain
  • phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
  • EFh_PI-PLC
  • phosphoinositide phospholipase C
  • Phosphatidylinositol-specific phospholipase C, X domain
  • Phospholipase C, catalytic domain (part: domain X)
  • Phosphoinositide-specific phospholipase C, efhand-like
  • EF hand
  • Phospholipase C, catalytic domain (part: domain Y)
  • PH domain
  • Protein kinase C conserved region 2 (CalB)
  • C2 domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • insomnia
  • hypertension
  • alopecia
  • male infertility
  • esophageal squamous cell carcinoma
  • esophageal squamous cell cancer
  • migraines
regulated by
regulates
role in cell
  • cell viability
  • G1 phase
  • proliferation
  • apoptosis
  • migration
  • invasion by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcd3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • labyrinthine layer blood vessel development
  • angiogenesis
  • lipid catabolic process
  • regulation of cell proliferation
  • intracellular signal transduction

Cellular Component

Where in the cell the gene product is active
  • cleavage furrow
  • cytoplasm
  • plasma membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • phosphatidylinositol phospholipase C activity
  • metal ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.