Tspan6 Gene Summary [Mouse]
Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of cytoplasmic pattern recognition receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in 1st branchial arch; jaw; and pancreas epithelium. Orthologous to human TSPAN6 (tetraspanin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan6 |
| Official Name | tetraspanin 6 [Source:MGI Symbol;Acc:MGI:1926264] |
| Ensembl ID | ENSMUSG00000067377 |
| Bio databases IDs | |
| Aliases | tetraspanin 6 |
| Synonyms | 6720473L21RIK, AI316786, T245, tetraspanin 6, Tm4sf, TM4SF6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Tspan6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding