Rab14 Gene Summary [Mouse]
Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in Golgi to endosome transport; fibroblast growth factor receptor signaling pathway; and regulation of embryonic development. Predicted to be located in several cellular components, including Golgi stack; apical plasma membrane; and cytoplasmic vesicle. Predicted to be active in early endosome membrane; phagocytic vesicle; and synaptic vesicle membrane. Orthologous to human RAB14 (RAB14, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab14 |
| Official Name | RAB14, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1915615] |
| Ensembl ID | ENSMUSG00000026878 |
| Bio databases IDs | |
| Aliases | RAB14, member RAS oncogene family |
| Synonyms | 0610030G24Rik, 2810475J17Rik, A830021G03RIK, D030017L14RIK, FBP, RAB14, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- myosin binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- Alzheimer disease
- organismal death
- neonatal late-onset sepsis
role in cell
- expression in
- migration
- invasion by
- formation
- maturation
- epithelial-mesenchymal transition
- delivery in
- autophagy in
- delivery
- redistribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- synaptic vesicle membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- endomembrane system
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- tertiary granule membrane
- cytosol
- apical membrane
- Golgi stacks
- endosomal compartment
- endosomal membrane
- alveolar epithelial lamellar bodies
- recycling endosomes
- early endosomes
- late endosomes
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- sorting endosomes
- Golgi vesicles
- phagosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- intracellular transport
- phagolysosome assembly involved in apoptotic cell clearance
- regulation of embryonic development
- fibroblast growth factor receptor signaling pathway
- phagosome maturation
- intracellular protein transport
- defense response to bacterium
- Golgi to endosome transport
- vesicle-mediated transport
- early endosome to Golgi transport
- endosomal vesicle fusion
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network transport vesicle
- phagocytic vesicle
- late endosome
- rough endoplasmic reticulum
- Golgi membrane
- Golgi stack
- lysosomal membrane
- plasma membrane
- lysosome
- early endosome membrane
- early endosome
- trans-Golgi network
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- nuclear outer membrane-endoplasmic reticulum membrane network
- cilium
- cytosol
- endomembrane system
- recycling endosome
- recycling endosome membrane
- tertiary granule membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding
- myosin V binding