S100a9 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in peptidyl-cysteine S-nitrosylation; positive regulation of blood coagulation; and regulation of translation. Acts upstream of or within several processes, including astrocyte development; leukocyte chemotaxis; and regulation of integrin biosynthetic process. Part of S100A9 complex. Is active in cornified envelope. Is expressed in several structures, including jaw; liver; otic capsule; skeleton; and spleen red pulp. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A9 (S100 calcium binding protein A9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a9 |
| Official Name | S100 calcium binding protein A9 (calgranulin B) [Source:MGI Symbol;Acc:MGI:1338947] |
| Ensembl ID | ENSMUSG00000056071 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A9 (calgranulin B) |
| Synonyms | 60B8AG, BEE22, CAGB, calgranulin B, CFAG, CGLB, GAGB, L1AG, Leukocyte l1 complex heavy chain, LIAG, MAC387, MIF, MIGRATION INHIBITORY FACTOR RELATED protein 14, MRP14, NIF, P14, S100 calcium binding protein A9, S100 calcium binding protein A9 (calgranulin B) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S100a9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- zinc ion binding
- EF-hand domain pair
- calcium ion binding
- EFh
- arachidonic acid binding
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the S100a9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- esophageal squamous cell cancer
- squamous cell cancer
- epithelial neoplasia
- rheumatoid arthritis
- systemic lupus erythematosus
- ischemic stroke
- osteoarthritis
- acne
- idiopathic pulmonary fibrosis
role in cell
- quantity
- expression in
- proliferation
- phagocytosis by
- phosphorylation in
- activation in
- binding
- migration
- invasion by
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- gelatinase granule fractions
- detergent resistant lipid raft fraction
- cornified envelope
- extracellular vesicles
- secretory granule lumen
- cytoskeleton
- Extracellular Space
- membrane surface
- Plasma Membrane
- cytosol
- nucleoli
- specific granules
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S100a9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of respiratory burst involved in inflammatory response
- astrocyte development
- endothelial cell migration
- positive regulation of NF-kappaB transcription factor activity
- inflammatory response
- positive regulation of cell growth
- autophagy
- apoptotic process
- positive regulation of neuron projection development
- neutrophil aggregation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- defense response to fungus
- positive regulation of intrinsic apoptotic signaling pathway
- peptidyl-cysteine S-nitrosylation
- regulation of toll-like receptor signaling pathway
- positive regulation of inflammatory response
- cell-cell signaling
- regulation of integrin biosynthetic process
- defense response to bacterium
- chronic inflammatory response
- sequestering of zinc ion
- leukocyte migration involved in inflammatory response
- peptidyl-cysteine S-trans-nitrosylation
- innate immune response
- regulation of cytoskeleton organization
- neutrophil chemotaxis
- response to lipopolysaccharide
- autocrine signaling
- modification of morphology or physiology of other organism
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- Toll-like receptor 4 binding
- protein binding
- antioxidant activity
- calcium ion binding
- calcium-dependent protein binding
- arachidonic acid binding
- RAGE receptor binding
- microtubule binding