Rbm5 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system; lung; sensory organ; and testis. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbm5 |
| Official Name | RNA binding motif protein 5 [Source:MGI Symbol;Acc:MGI:1933204] |
| Ensembl ID | ENSMUSG00000032580 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 5 |
| Synonyms | D030069N10RIK, G15, H37, LUCA-15, RMB5, RNA binding motif protein 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- Zn-finger in Ran binding protein and others
- G-patch domain
- RNA recognition motif
- mRNA binding
- OCRE domain
- protein binding
- zinc finger domain
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- tumorigenesis
- Alzheimer disease
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- paroxysmal nocturnal hemoglobinuria
- bone resorption disorder
- infection by HIV-1
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- growth
- formation
- formation in
- G2/M phase
- migration
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- apoptotic process
- RNA processing
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- metal ion binding
- mRNA binding