Trabd2b Gene Summary [Mouse]
Predicted to enable Wnt-protein binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Predicted to be located in nucleoplasm. Predicted to be active in organelle membrane and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; neural ectoderm; and respiratory system. Orthologous to human TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trabd2b |
| Official Name | TraB domain containing 2B [Source:MGI Symbol;Acc:MGI:3650152] |
| Ensembl ID | ENSMUSG00000070867 |
| Bio databases IDs | |
| Aliases | TraB domain containing 2B |
| Synonyms | Gm12824, Hkat, LOC230628, LOC284542, LOC388630, LOC684165, RGD1564942, TIKI2, TraB domain containing 2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trabd2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- diverse proteins related to the Tiki and TraB protease domains
- peptidase
- protein binding
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trabd2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- organelle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- Wnt-protein binding
- metalloendopeptidase activity