Tgfbrap1 Gene Summary [Mouse]
Predicted to enable SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including endosomal vesicle fusion; endosome to lysosome transport; and regulation of DNA-templated transcription. Part of CORVET complex. Is expressed in several structures, including gonad; gut; hemolymphoid system; liver; and lung. Orthologous to human TGFBRAP1 (transforming growth factor beta receptor associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgfbrap1 |
| Official Name | transforming growth factor, beta receptor associated protein 1 [Source:MGI Symbol;Acc:MGI:2447427] |
| Ensembl ID | ENSMUSG00000070939 |
| Bio databases IDs | |
| Aliases | transforming growth factor, beta receptor associated protein 1 |
| Synonyms | 3110018K12RIK, TGF beta receptor ASSOCIATED protein 1, TGF β receptor ASSOCIATED protein 1, transforming growth factor beta receptor associated protein 1, transforming growth factor, beta receptor associated protein 1, transforming growth factor β receptor associated protein 1, transforming growth factor, β receptor associated protein 1, TRAP-1, VPS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgfbrap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- receptor binding domain
- transforming growth factor-beta receptor binding
- CNH domain
- Region in Clathrin and VPS
- Vacuolar sorting protein 39 domain 2
- protein binding
- Clathrin heavy chain repeat homology
- Vacuolar sorting protein 39 domain 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgfbrap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- signal transduction
- autophagy
- transforming growth factor beta receptor signaling pathway
- regulation of transcription, DNA-dependent
- endosome to lysosome transport
- endosomal vesicle fusion
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- CORVET complex
- intracellular membrane-bounded organelle
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- transforming growth factor beta receptor binding