Nrbf2 Gene Summary [Mouse]
Predicted to enable nuclear receptor binding activity and transcription coactivator activity. Involved in autophagy; regulation of lipid kinase activity; and response to endoplasmic reticulum stress. Part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human NRBF2 (nuclear receptor binding factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrbf2 |
| Official Name | nuclear receptor binding factor 2 [Source:MGI Symbol;Acc:MGI:1354950] |
| Ensembl ID | ENSMUSG00000075000 |
| Bio databases IDs | |
| Aliases | nuclear receptor binding factor 2 |
| Synonyms | AC155712.2, BAB70833.1, COPR, COPR1, COPR2, nuclear receptor binding factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrbf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- MIT domain of nuclear receptor-binding factor 2
- Nuclear receptor-binding factor 2, autophagy regulator
- protein binding
Pathways
Biological processes and signaling networks where the Nrbf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
role in cell
- binding in
- proliferation
- autophagy by
- autophagic flux
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrbf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- phosphatidylinositol 3-kinase complex, class III
- cytoplasmic vesicle
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding