Vps41 Gene Summary [Mouse]
Enables microtubule binding activity. Predicted to be involved in several processes, including cellular response to starvation; endosomal vesicle fusion; and vacuolar transport. Located in early endosome; late endosome membrane; and microtubule cytoskeleton. Part of HOPS complex. Is expressed in embryo; extraembryonic component; and primitive endoderm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Orthologous to human VPS41 (VPS41 subunit of HOPS complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Vps41 |
| Official Name | VPS41 HOPS complex subunit [Source:MGI Symbol;Acc:MGI:1929215] |
| Ensembl ID | ENSMUSG00000041236 |
| Bio databases IDs | |
| Aliases | VPS41 HOPS complex subunit |
| Synonyms | HVPS41, hVps41p, HVSP41, mVam2, RGD1560511, SCAR29, Vam2, VPS41 HOPS complex subunit, VPS41 subunit of HOPS complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Region in Clathrin and VPS
- protein binding
- Clathrin heavy chain repeat homology
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Vps41 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- colorectal cancer
- autosomal recessive spinocerebellar ataxia type 29
- hyper-IgD syndrome
- neuroticism
- infection by feline infectious peritonitis virus
- infection by murine hepatitis virus
role in cell
- fusion
- transport
- dipeptide repeat protein sensitivity
- pravastatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cellular membrane
- vesicles
- lysosome
- Golgi Apparatus
- microtubules
- cytosol
- lysosome membrane
- endosomal membrane
- early endosomes
- late endosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- vesicle-mediated transport
- endosome to lysosome transport
- endosomal vesicle fusion
- cellular response to starvation
- protein targeting to vacuole
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- late endosome
- Golgi apparatus
- lysosomal membrane
- lysosome
- early endosome membrane
- late endosome membrane
- cytosol
- endosome membrane
- AP-3 adaptor complex
- clathrin-coated vesicle
- clathrin complex
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- microtubule binding