Spx Gene Summary [Mouse]
Predicted to enable neuropeptide hormone activity; type 2 galanin receptor binding activity; and type 3 galanin receptor binding activity. Involved in long-chain fatty acid import into cell and negative regulation of appetite. Predicted to be located in dense core granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in esophagus and stomach fundus submucosa. Orthologous to human SPX (spexin hormone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spx |
| Official Name | spexin hormone [Source:MGI Symbol;Acc:MGI:2442262] |
| Ensembl ID | ENSMUSG00000071112 |
| Bio databases IDs | |
| Aliases | spexin hormone |
| Synonyms | B230216G23Rik, C12orf39, LOC686427, Npq, spexin hormone, SPX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuropeptide secretory protein family, NPQ, spexin
- G-protein-coupled receptor binding
- protein binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- polycystic ovary syndrome
- thyroid carcinoma
- epithelial thyroid cancer
regulates
- beta-estradiol
- DNA promoter
- DNA endogenous promoter
- progesterone
- RNA polymerase II
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Extracellular Space
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- signal transduction
- negative regulation of appetite
- positive regulation of systemic arterial blood pressure
- negative regulation of heart rate
- negative regulation of renal sodium excretion
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- dense core granule
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity