Cdc20 Gene Summary [Mouse]
Predicted to enable several functions, including anaphase-promoting complex binding activity; histone deacetylase binding activity; and ubiquitin ligase activator activity. Involved in metaphase/anaphase transition of meiosis I; positive regulation of synapse maturation; and positive regulation of synaptic plasticity. Acts upstream of or within mitotic sister chromatid cohesion; mitotic spindle assembly; and regulation of meiotic nuclear division. Located in centrosome and kinetochore. Is expressed in several structures, including brain; early conceptus; female reproductive system; hemolymphoid system; and trigeminal ganglion. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc20 |
| Official Name | cell division cycle 20 [Source:MGI Symbol;Acc:MGI:1859866] |
| Ensembl ID | ENSMUSG00000006398 |
| Bio databases IDs | |
| Aliases | cell division cycle 20 |
| Synonyms | 2310042N09Rik, bA276H19.3, CDC20A, cell division cycle 20, OOMD14, OZEMA14, p55CDC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- Mad2 binding domain
- binding protein
- WD40 repeats
- MAPK phosphorylation site
- protein binding activity, bridging
- WD domain, G-beta repeat
- histone deacetylase binding
- WD40
- protein binding
- substrate binding domain
Pathways
Biological processes and signaling networks where the Cdc20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- epithelial cancer
- organismal death
- liver cancer
- hepatocellular carcinoma
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast carcinoma
role in cell
- expression in
- phosphorylation in
- cell death
- apoptosis
- cellular infiltration by
- growth
- quantity
- proliferation
- cell cycle progression
- metaphase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- perinuclear region
- centrosome
- microtubules
- cytosol
- nucleoplasm
- nuclear rim
- spindle pole
- spindle fibers
- meiotic spindles
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- positive regulation of synapse maturation
- mitotic sister chromatid cohesion
- regulation of meiosis
- nervous system development
- positive regulation of mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
- cell division
- regulation of meiotic cell cycle
- positive regulation of synaptic plasticity
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- cell differentiation
- protein ubiquitination
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- anaphase-promoting complex
- spindle
- spindle pole
- cytosol
- mitotic checkpoint complex
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- anaphase-promoting complex binding