Rnf5 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Acts upstream of or within several processes, including negative regulation of autophagy; protein destabilization; and regulation of autophagosome assembly. Located in membrane. Is expressed in several structures, including limb; nervous system; testis; and urinary system. Orthologous to human RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf5 |
| Official Name | ring finger protein 5 [Source:MGI Symbol;Acc:MGI:1860076] |
| Ensembl ID | ENSMUSG00000015478 |
| Bio databases IDs | |
| Aliases | ring finger protein 5 |
| Synonyms | 2410131O05Rik, NG2, RING5, ring finger protein 5, RMA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- ER targeting sequence
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- binding protein
- zinc ion binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- transmembrane domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- idiopathic pulmonary fibrosis
- Takayasu arteritis
- perivascular fibrosis
- membranous glomerulonephritis
- melanoma
- melanoma cancer
role in cell
- expression in
- apoptosis
- degradation in
- proliferation
- autophagy by
- synthesis in
- Lys29 polyubiquitination in
- ubiquitination in
- polyubiquitination in
- cross-sectional area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- response to bacterium
- protein K48-linked ubiquitination
- transmembrane transport
- negative regulation of autophagy
- protein catabolic process
- regulation of autophagic vacuole assembly
- protein K63-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- small protein conjugating enzyme binding
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- protein binding