Smpd5 Gene Summary [Mouse]
Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Acts upstream of or within ceramide metabolic process. Located in endoplasmic reticulum membrane and mitochondrial membrane. Orthologous to human SMPD5 (sphingomyelin phosphodiesterase 5 (pseudogene)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smpd5 |
| Official Name | sphingomyelin phosphodiesterase 5 [Source:MGI Symbol;Acc:MGI:3709877] |
| Ensembl ID | ENSMUSG00000071724 |
| Bio databases IDs | |
| Aliases | sphingomyelin phosphodiesterase 5 |
| Synonyms | Gm10345, LOC100046038, MA-nSMase, sphingomyelin phosphodiesterase 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smpd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sphingomyelin phosphodiesterase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- enzyme
Pathways
Biological processes and signaling networks where the Smpd5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane