Ndufa11 Gene Summary [Mouse]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in communication disorder and nuclear type mitochondrial complex I deficiency 14. Orthologous to human NDUFA11 (NADH:ubiquinone oxidoreductase subunit A11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa11 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A11 [Source:MGI Symbol;Acc:MGI:1917125] |
| Ensembl ID | ENSMUSG00000002379 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A11 |
| Synonyms | 2010012C24Rik, AV006275, B14.7, CI-B14.7, Complex I-B14.7, MC1DN14, NADH:ubiquinone oxidoreductase subunit A11, ZINC FINGER |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufa11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- Tim17/Tim22/Tim23/Pmp24 family
Pathways
Biological processes and signaling networks where the Ndufa11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial disorder
- adult acute myeloid leukemia
- lung squamous cell carcinoma
- squamous cell lung cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- nuclear type 14 mitochondrial complex I deficiency
- insulin resistance
role in cell
- expression in
- phosphorylation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufa11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding