mt-Atp8 Gene Summary [Mouse]
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Is expressed in heart; liver; and metanephros. Human ortholog(s) of this gene implicated in multiple sclerosis and urinary bladder cancer. Orthologous to human MT-ATP8 (mitochondrially encoded ATP synthase membrane subunit 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | mt-Atp8 |
| Official Name | mitochondrially encoded ATP synthase 8 [Source:MGI Symbol;Acc:MGI:99926] |
| Ensembl ID | ENSMUSG00000064356 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded ATP synthase 8 |
| Synonyms | ATP8, Atp synthase (f0f1), subunit a6l, ATP Synthase F0 Subunit 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mt-Atp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP8
- ATP synthase protein 8
- enzyme
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cristae-like membrane
- Mitochondria
- mitochondrial membrane