Cox5a Gene Summary [Mouse]
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; hindlimb musculature; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cox5a |
| Official Name | cytochrome c oxidase subunit 5A [Source:MGI Symbol;Acc:MGI:88474] |
| Ensembl ID | ENSMUSG00000000088 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 5A |
| Synonyms | CcOX, COX, COX-VA, cytochrome c oxidase subunit 5A, Cytochrome c oxidase subunit va, MC4DN20, Mitochondrial Cytochrome C Oxidase Va, VA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- mitochondrial presequence
- electron carrier
- Cyt_c_Oxidase_Va
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cox5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- nuclear type 20 mitochondrial complex IV deficiency
- insulin resistance
- Alzheimer disease
- primary ovarian cancer
- bipolar disorder
regulates
- cytochrome-c oxidase
role in cell
- apoptosis
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity
- metal ion binding
- electron carrier activity