Ptgr2 Gene Summary [Mouse]
Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in prostaglandin metabolic process. Located in mitochondrion. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgr2 |
| Official Name | prostaglandin reductase 2 [Source:MGI Symbol;Acc:MGI:1916372] |
| Ensembl ID | ENSMUSG00000072946 |
| Bio databases IDs | |
| Aliases | prostaglandin reductase 2 |
| Synonyms | 1810016I24RIK, 9130222H03Rik, 9630002F03Rik, B830026H24Rik, HEL-S-298, PGR-2, PRG-2, prostaglandin reductase 2, ZADH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 15-oxoprostaglandin 13-oxidase
- N-terminal domain of oxidoreductase
- MDR
- Zinc-binding dehydrogenase
- leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- chronic obstructive pulmonary disease
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- 13-prostaglandin reductase activity
- 15-oxoprostaglandin 13-oxidase activity