Tpm4 Gene Summary [Mouse]
Enables actin filament binding activity. Involved in platelet formation. Located in cortical cytoskeleton and podosome. Is expressed in neural retina. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tpm4 |
| Official Name | tropomyosin 4 [Source:MGI Symbol;Acc:MGI:2449202] |
| Ensembl ID | ENSMUSG00000031799 |
| Bio databases IDs | |
| Aliases | tropomyosin 4 |
| Synonyms | 2610528G24RIK, BDPLT25, HEL-S-108, Tm4, Tpm4.2, Tpm4.2cy, tropomyosin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Tropomyosin
- structural constituent of muscle
- Tropomyosin like
- protein homodimerization
- protein binding
- identical protein binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tpm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- ovarian cancer
- diabetic nephropathy
- organismal death
- platelet-type bleeding disorder 25
- hemorrhagic disease
- osteoporosis
- breast adenocarcinoma
- COVID-19
- juvenile dermatomyositis
regulates
- F Actin
- fascin
- Myosin2
role in cell
- proliferation
- migration
- formation
- invasion by
- assembly in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cortical cytoskeleton
- cytoskeleton
- cilia
- podosomes
- actin cytoskeleton
- cell cortex
- Nucleus
- cytosol
- myofibrils
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- osteoblast differentiation
- platelet formation
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- membrane
- stress fiber
- cytosol
- actin filament
- muscle thin filament tropomyosin
- cortical cytoskeleton
- podosome
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- structural constituent of muscle
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- calcium ion binding