Rpl35 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 19. Orthologous to human RPL35 (ribosomal protein L35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl35 |
| Official Name | ribosomal protein L35 [Source:MGI Symbol;Acc:MGI:1913739] |
| Ensembl ID | ENSMUSG00000062997 |
| Bio databases IDs | |
| Aliases | ribosomal protein L35 |
| Synonyms | 2410039E09Rik, DBA19, L35, MGC72958, Ribosomal protein L35, uL29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal L29 protein
- Ribosomal_L29_HIP
- structural constituent of ribosome
- mRNA binding
- ribonucleoprotein binding
- protein binding
Pathways
Biological processes and signaling networks where the Rpl35 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic steatohepatitis
- survival
- myelodysplastic syndrome
- Diamond-Blackfan anemia type 19
- lymphoma
- lymphomagenesis
- nonalcoholic fatty liver disease
role in cell
- cell death
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- ribosome
- cytosol
- nucleoli
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- structural constituent of ribosome
- mRNA binding