Cmtm2a Gene Summary [Mouse]
Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmtm2a |
| Official Name | CKLF-like MARVEL transmembrane domain containing 2A [Source:MGI Symbol;Acc:MGI:2447160] |
| Ensembl ID | ENSMUSG00000074127 |
| Bio databases IDs | |
| Aliases | CKLF-like MARVEL transmembrane domain containing 2A |
| Synonyms | 1700001K04Rik, 1700041N15Rik, 1700063K20Rik, ARR19, C32, Chemokine like factor, Cklf, Cklf1, CKLF3, CKLF4, CKLF5, CKLF like MARVEL transmembrane domain containing 2, CKLF-like MARVEL transmembrane domain containing 2A, CKLF-like MARVEL transmembrane domain containing 2B, CKLFSF2, Cklfsf2-1b, Cklfsf2a, Cmtm2a, Cmtm2b, UCK-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmtm2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- transcription regulator
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmtm2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity