Marchf6 Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and ubiquitin-specific protease binding activity. Predicted to be involved in ERAD pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Marchf6 |
| Official Name | membrane associated ring-CH-type finger 6 [Source:MGI Symbol;Acc:MGI:2442773] |
| Ensembl ID | ENSMUSG00000039100 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 6 |
| Synonyms | 3830408G03, DOA10, F830029L24Rik, FAME3, FCMTE3, MARCH6, MARCH-VI, membrane associated ring-CH-type finger 6, mKIAA0597, RGD1310927, RGD1565757, RNF176, TEB4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Marchf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- papillary thyroid cancer
- familial adult myoclonic epilepsy type 3
role in cell
- phosphorylation in
- apoptosis
- proliferation
- migration
- cell cycle progression
- colony formation
- imatinib sensitivity
- transformation
- stabilization in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Marchf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein ubiquitination
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER ubiquitin ligase complex
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding
- enzyme binding