Grem1 Gene Summary [Mouse]
Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including circulatory system development; nephron epithelium morphogenesis; and regulation of primary metabolic process. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grem1 |
| Official Name | gremlin 1, DAN family BMP antagonist [Source:MGI Symbol;Acc:MGI:1344337] |
| Ensembl ID | ENSMUSG00000074934 |
| Bio databases IDs | |
| Aliases | gremlin 1, DAN family BMP antagonist |
| Synonyms | C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, Grem, GREMLIN, GREMLIN 1, gremlin 1, DAN family BMP antagonist, HMPS, HMPS1, IHG-2, ld, MPSH, PIG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- transmembrane receptor protein tyrosine kinase activator
- morphogen
- binding protein
- cytokine binding
- protein homodimerization
- receptor agonist activity
- protein binding
- vascular endothelial growth factor receptor binding
- glycosylation site
- DAN domain
Pathways
Biological processes and signaling networks where the Grem1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- infiltrating ductal breast carcinoma
- atherosclerosis
- colon carcinoma
- adenoma formation
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- diabetic nephropathy
role in cell
- expression in
- growth
- phosphorylation in
- apoptosis
- quantity
- cell viability
- proliferation
- activation in
- differentiation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sequestering of BMP from receptor via BMP binding
- negative regulation of bone trabecula formation
- positive regulation of cell proliferation
- negative regulation of bone remodeling
- cell migration involved in sprouting angiogenesis
- negative regulation of bone mineralization involved in bone maturation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- proximal/distal pattern formation
- negative regulation of osteoclast proliferation
- negative regulation of osteoblast differentiation
- embryonic limb morphogenesis
- regulation of epithelial to mesenchymal transition
- negative regulation of bone mineralization
- determination of dorsal identity
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- cardiac muscle cell differentiation
- negative regulation of monocyte chemotaxis
- negative regulation of SMAD protein import into nucleus
- positive regulation of receptor activity
- positive regulation of receptor internalization
- positive regulation of peptidyl-tyrosine autophosphorylation
- limb development
- signal transduction
- cell morphogenesis
- cell-cell signaling
- ureteric bud formation
- cardiac muscle cell myoblast differentiation
- organ morphogenesis
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of branching involved in ureteric bud morphogenesis
- positive regulation of telomerase activity
- mesenchymal to epithelial transition involved in metanephros morphogenesis
- regulation of focal adhesion assembly
- negative regulation of apoptotic process
- signal transduction by p53 class mediator
- regulation of stress-activated MAPK cascade
- negative regulation of chondrocyte differentiation
- collagen fibril organization
- negative regulation of osteoblast proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cell surface
Molecular Function
What the gene product does at the molecular level
- BMP binding
- protein homodimerization activity
- protein binding
- vascular endothelial growth factor receptor 2 binding
- transmembrane receptor protein tyrosine kinase activator activity
- receptor agonist activity
- cytokine activity
- morphogen activity