Slit2 Gene Summary [Mouse]
The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Slit2 |
| Official Name | slit guidance ligand 2 [Source:MGI Symbol;Acc:MGI:1315205] |
| Ensembl ID | ENSMUSG00000031558 |
| Bio databases IDs | |
| Aliases | slit guidance ligand 2 |
| Synonyms | b2b1200.1Clo, Drad-1, E030015M03Rik, E130320P19Rik, mKIAA4141, SLIL3, slit guidance ligand 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slit2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- chemorepellant
- Leucine rich repeat
- Leucine Rich repeats (2 copies)
- cleavage site
- identical protein binding
- EGF_CA
- leucine-rich repeat
- GTPase inhibitor
- cytoplasmic domain
- laminin G domain
- cysteine rich domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- LamG
- Human growth factor-like EGF
- Leucine rich repeat C-terminal domain
- protein binding
- receptor binding
- EGF-like domain
- laminin-G repeat
- binding protein
- laminin binding
- protein homodimerization
- Leucine rich repeat N-terminal domain
- heparin binding
Pathways
Biological processes and signaling networks where the Slit2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- melanoma
- melanoma cancer
- metabolic syndrome X
- epithelial cancer
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
role in cell
- differentiation
- apoptosis
- activation in
- phosphorylation in
- expression in
- cell death
- generation in
- proliferation
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- insulin granule
- Cytoplasm
- cell surface
- Plasma Membrane
- extracellular matrix
- cellular protrusions
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slit2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Roundabout signaling pathway
- negative chemotaxis
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
- motor axon guidance
- chemorepulsion involved in postnatal olfactory bulb interneuron migration
- axon guidance
- cell migration involved in sprouting angiogenesis
- branching morphogenesis of a tube
- corticospinal neuron axon guidance through spinal cord
- positive regulation of axonogenesis
- negative regulation of chemokine-mediated signaling pathway
- negative regulation of cell growth
- negative regulation of smooth muscle cell chemotaxis
- negative regulation of smooth muscle cell migration
- negative regulation of mononuclear cell migration
- negative regulation of endothelial cell migration
- apoptotic process involved in luteolysis
- negative regulation of monocyte chemotaxis
- negative regulation of lamellipodium assembly
- retinal ganglion cell axon guidance
- aortic valve morphogenesis
- induction of negative chemotaxis
- negative regulation of cellular response to growth factor stimulus
- negative regulation of neutrophil chemotaxis
- pulmonary valve morphogenesis
- negative regulation of vascular permeability
- negative regulation of retinal ganglion cell axon guidance
- ventricular septum morphogenesis
- axon extension involved in axon guidance
- negative regulation of small GTPase mediated signal transduction
- negative regulation of leukocyte chemotaxis
- negative regulation of actin filament polymerization
- ureteric bud development
- negative regulation of protein phosphorylation
- positive regulation of apoptotic process
- cellular response to hormone stimulus
- negative regulation of cell migration
- response to cortisol stimulus
- cellular response to heparin
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- Roundabout binding
- identical protein binding
- protein homodimerization activity
- protein binding
- GTPase inhibitor activity
- proteoglycan binding
- calcium ion binding
- heparin binding
- laminin-1 binding