Cgas Gene Summary [Mouse]
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | Cgas |
| Official Name | cyclic GMP-AMP synthase [Source:MGI Symbol;Acc:MGI:2442261] |
| Ensembl ID | ENSMUSG00000032344 |
| Bio databases IDs | |
| Aliases | cyclic GMP-AMP synthase |
| Synonyms | C6orf150, cyclic GMP-AMP synthase, D4, E330016A19Rik, h-cGAS, MB21D1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cgas often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- catalytic domain
- nucleotidyltransferase
- protein binding activity, bridging
- chromatin binding
- enzyme
- protein binding
- DNA binding
- binding protein
- Mab-21 protein HhH/H2TH-like domain
- double-stranded DNA binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization
- Mab-21 protein nucleotidyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- allergic airway inflammation
- dextran sodium sulfate-induced colitis
- glaucoma
- Huntington disease
- acute lung injury
- cerebral hemorrhage
- ulcerative colitis
- alcoholic steatohepatitis
role in cell
- activation in
- proliferation
- expression in
- phosphorylation in
- apoptosis
- cell death
- binding in
- signaling in
- quantity
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cgas gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- cGMP-mediated signaling
- negative regulation of double-strand break repair via homologous recombination
- positive regulation of type I interferon production
- determination of adult lifespan
- paracrine signaling
- positive regulation of defense response to virus by host
- response to DNA damage stimulus
- pattern recognition receptor signaling pathway
- cytoplasmic pattern recognition receptor signaling pathway
- cellular response to exogenous dsRNA
- activation of innate immune response
- regulation of immunoglobulin production
- innate immune response
- positive regulation of cellular senescence
- defense response to virus
- cAMP-mediated signaling
- regulation of T cell activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- site of double-strand break
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- DNA binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization activity
- protein binding
- metal ion binding
- nucleosome binding
- double-stranded DNA binding
- chromatin binding