Fsip2 Gene Summary [Mouse]
Predicted to act upstream of or within with a positive effect on protein localization to cilium and sperm axoneme assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 34. Orthologous to human FSIP2 (fibrous sheath interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fsip2 |
| Official Name | fibrous sheath-interacting protein 2 [Source:MGI Symbol;Acc:MGI:2664111] |
| Ensembl ID | ENSMUSG00000075249 |
| Bio databases IDs | |
| Aliases | fibrous sheath-interacting protein 2 |
| Synonyms | fibrous sheath-interacting protein 2, FLJ34780, LOC680325, RP23-221K3.2, SPGF34 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fsip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MAP7 (E-MAP-115) family
- protein binding
- Fibrous sheath-interacting protein 2
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm end piece
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fsip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- sperm axoneme assembly
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- sperm end piece
- sperm principal piece