Akap4 Gene Summary [Mouse]
Enables protein kinase A binding activity. Involved in flagellated sperm motility and spermatogenesis. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; establishment of protein localization; and sperm flagellum assembly. Located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap4 |
| Official Name | A kinase (PRKA) anchor protein 4 [Source:MGI Symbol;Acc:MGI:102794] |
| Ensembl ID | ENSMUSG00000050089 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 4 |
| Synonyms | AKAP 82, A-kinase anchoring protein 4, A kinase anchor protein 4, CT99, FSC1, hAKAP82, HI, mAKAP82, p82, PRKA4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- RII binding domain
- RI binding domain
- protein binding
- A-kinase anchor protein 110 kDa (AKAP 110)
- RI/RII binding domain
Pathways
Biological processes and signaling networks where the Akap4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- sperm end piece
- cytoskeleton
- cilia
- perinuclear region
- flagella
- fibrous sheath of sperm
- sperm midpiece
- sperm tail
- sperm fibrous sheath
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- sperm motility
- signal transduction
- protein localization
- establishment of localization in cell
- transmembrane receptor protein serine/threonine kinase signaling pathway
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- motile cilium
- perinuclear region of cytoplasm
- cytoskeleton
- sperm midpiece
- cytoplasm
- sperm end piece
- sperm principal piece
- flagellar fibrous sheath
- cAMP-dependent protein kinase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A binding