Acsf2 Gene Summary [Mouse]
Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including connective tissue; gonad; gut gland; immune system; and nervous system. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsf2 |
| Official Name | acyl-CoA synthetase family member 2 [Source:MGI Symbol;Acc:MGI:2388287] |
| Ensembl ID | ENSMUSG00000076435 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase family member 2 |
| Synonyms | ACSMW, acyl-CoA synthetase family member 2, AVYV493 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acsf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- AMP-binding enzyme
- CoA-ligase
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- enzyme
- protein binding
- amino acid adenylation domain
- AMP-binding enzyme C-terminal domain
Pathways
Biological processes and signaling networks where the Acsf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- adenoma formation
- lung squamous cell carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- squamous cell lung cancer
- aldosterone producing adrenocortical adenoma
- organismal death
- osteoarthritis
regulates
- acyl-coenzyme A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acsf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- long-chain fatty acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- medium-chain fatty acid-CoA ligase activity
- ATP binding
- protein binding
- long-chain fatty acid-CoA ligase activity