Slc25a10 Gene Summary [Mouse]

Enables malate transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in glyceraldehyde-3-phosphate biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in cerebral cortex ventricular layer; embryo; and testis. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Slc25a10
Official Name
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 [Source:MGI Symbol;Acc:MGI:1353497]
Ensembl ID
ENSMUSG00000025792
Bio databases IDs NCBI: 27376 Ensembl: ENSMUSG00000025792
Aliases solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms DIC, Dicarboxylate carrier, MTDPS19, solute carrier family 25 member 10, solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • thiosulfate transporter
  • inorganic phosphate transporter
  • porter
  • sulfate transporter
  • Mitochondrial carrier protein
  • malate transporter
  • dicarboxylic acid transporter
  • antiporter
  • protein binding
  • succinate transporter
  • transporter

Pathways

Biological processes and signaling networks where the Slc25a10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • mitochondrial DNA depletion syndrome 19
  • Mitochondrial complex I deficiency
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • mitochondrial disorder
  • insulin resistance
  • dental caries
regulated by
  • D-glucose
  • metribolone
  • methylprednisolone
  • thapsigargin
  • testosterone
  • PPARA
  • B lymphocytes
  • AGK
  • HUWE1
  • HNF4A
regulates
  • reactive oxygen species
  • ACACA
  • ion
  • malic acid
  • glyceraldehyde-3-phosphate
  • phosphate
  • SLC25A10
  • dynactin
  • dicarboxylic acid
role in cell
  • apoptosis
  • accumulation
  • insulin sensitivity
  • transport
  • gluconeogenesis in
  • transport in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • Mitochondria
  • mitochondrial inner membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sulfate transport
  • gluconeogenesis
  • dicarboxylic acid transport
  • lipid transport
  • ion transport
  • sulfide oxidation, using sulfide:quinone oxidoreductase
  • thiosulfate transport
  • glyceraldehyde-3-phosphate biosynthetic process
  • oxaloacetate transport
  • succinate transmembrane transport
  • malate transmembrane transport
  • phosphate ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • mitochondrion
  • mitochondrial inner membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • antiporter activity
  • oxaloacetate transmembrane transporter activity
  • succinate transmembrane transporter activity
  • malate transmembrane transporter activity
  • dicarboxylic acid transmembrane transporter activity
  • thiosulfate transmembrane transporter activity
  • sulfate transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.