Nrarp Gene Summary [Mouse]
Acts upstream of or within several processes, including angiogenesis; positive regulation of vascular endothelial cell proliferation; and somite rostral/caudal axis specification. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and retina. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrarp |
| Official Name | Notch-regulated ankyrin repeat protein [Source:MGI Symbol;Acc:MGI:1914372] |
| Ensembl ID | ENSMUSG00000078202 |
| Bio databases IDs | |
| Aliases | Notch-regulated ankyrin repeat protein |
| Synonyms | 2700054M22Rik, LOC100363786, LOC100912697, LOC687161, MGC61598, NOTCH regulated ankyrin repeat protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrarp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- growth failure
- androgenic alopecia
- choroidal neovascularization
- preeclampsia
regulates
- RNA polymerase II
- DNA endogenous promoter
- DNA promoter
- NOTCH
role in cell
- proliferation
- differentiation
- hyperproduction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrarp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of T cell differentiation
- Notch signaling pathway
- patterning of blood vessels
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of endothelial cell proliferation
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- negative regulation of Notch signaling pathway
- somite rostral/caudal axis specification
Molecular Function
What the gene product does at the molecular level
- protein binding