Clk1 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and thyroid gland. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Clk1 |
| Official Name | CDC-like kinase 1 [Source:MGI Symbol;Acc:MGI:107403] |
| Ensembl ID | ENSMUSG00000026034 |
| Bio databases IDs | |
| Aliases | CDC-like kinase 1 |
| Synonyms | AL022790, CDC-LIKE KINASE 1, CLK, CLK/STY, STY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
Pathways
Biological processes and signaling networks where the Clk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- organismal death
- liver cancer
- Huntington disease
- tumorigenesis
- Waldenström macroglobulinemia
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- expression in
- phosphorylation in
- proliferation
- replication in
- splicing in
- ploidy
- splicing regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- non-membrane spanning protein tyrosine kinase activity
- protein serine/threonine kinase activity