Zan Gene Summary [Mouse]
Predicted to enable extracellular matrix binding activity. Acts upstream of or within regulation of binding activity of sperm to zona pellucida. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human ZAN (zonadhesin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zan |
| Official Name | zonadhesin [Source:MGI Symbol;Acc:MGI:106656] |
| Ensembl ID | ENSMUSG00000079173 |
| Bio databases IDs | |
| Aliases | zonadhesin |
| Synonyms | Zan-test, zonadhesin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zan often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- RCSD region
- extracellular matrix binding
- von Willebrand factor type D domain
- C8 domain
- EGF_CA
- Trypsin Inhibitor like cysteine rich domain
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- von Willebrand factor type C domain
- trypsin inhibitor-like cysteine rich domain
- von Willebrand factor (vWF) type D domain
- Protein of unknown function (DUF3246)
- MAM domain, meprin/A5/mu
Pathways
Biological processes and signaling networks where the Zan gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zan gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- plasma membrane