Myrf Gene Summary [Mouse]
Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of DNA-templated transcription. Located in endoplasmic reticulum membrane and nucleus. Is expressed in pigmented retinal epithelium; spinal cord; and spinal cord marginal layer. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myrf |
| Official Name | myelin regulatory factor [Source:MGI Symbol;Acc:MGI:2684944] |
| Ensembl ID | ENSMUSG00000036098 |
| Bio databases IDs | |
| Aliases | myelin regulatory factor |
| Synonyms | 11orf9, 6030439E18, C11orf9, CUGS, Gm1804, Gm98, KIAA0954, MMERV, MRF, myelin regulatory factor, Ndt80, pqn-47, RGD1306622 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myrf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- NDT80 / PhoG like DNA-binding family
- protein binding
- Peptidase_S74_CIMCD
- Myelin regulatory factor ICA domain
- transcription factor activity
- identical protein binding
- Myelin gene regulatory factor C-terminal domain 2
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- ulcerative colitis
- hereditary disorder
- Crohn disease
- cardiac-urogenital syndrome
- serous ovarian adenocarcinoma
- serous ovarian cancer
- atopic dermatitis
- mild encephalitis/encephalopathy with reversible myelin vacuolization
- colorectal cancer
role in cell
- apoptosis
- expression in
- damage
- differentiation
- cellular infiltration
- association
- downregulation in
- upregulation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myrf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- oligodendrocyte differentiation
- central nervous system myelination
- positive regulation of transcription, DNA-dependent
- central nervous system myelin maintenance
- response to cocaine
- protein autoprocessing
- response to immobilization stress
- positive regulation of myelination
- positive regulation of oligodendrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- sequence-specific DNA binding
- peptidase activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity