Zp3 Gene Summary [Mouse]
Enables receptor ligand activity. A structural constituent of egg coat. Involved in several processes, including oogenesis; positive regulation of acrosome reaction; and regulation of gene expression. Acts upstream of or within binding activity of sperm to zona pellucida. Located in collagen-containing extracellular matrix and plasma membrane. Is expressed in ovary; ovary preantral follicle; and testis. Orthologous to human ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zp3 |
| Official Name | zona pellucida glycoprotein 3 [Source:MGI Symbol;Acc:MGI:99215] |
| Ensembl ID | ENSMUSG00000004948 |
| Bio databases IDs | |
| Aliases | zona pellucida glycoprotein 3 |
| Synonyms | OOMD3, OZEMA3, zona pellucida glycoprotein 3, ZP3A, ZP3B, ZPC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- furin cleavage consensus sequence
- enzyme binding
- extracellular matrix structural constituent
- receptor agonist activity
- protein binding
- carbohydrate binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Zp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- delayed hypersensitive reaction
- oocyte maturation defect type 3
- autoimmune disease
- autoimmune ovarian disease
- empty follicle syndrome
role in cell
- binding
- quantity
- expression in
- proliferation
- migration
- activation
- formation in
- formation
- acrosome reaction
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- zona pellucida fraction
- cell surface
- intracellular space
- cellular membrane
- Plasma Membrane
- vesicles
- zona pellucida
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of binding of sperm to zona pellucida
- positive regulation of inflammatory response
- positive regulation of T cell proliferation
- humoral immune response mediated by circulating immunoglobulin
- positive regulation of leukocyte migration
- binding of sperm to zona pellucida
- oocyte development
- negative regulation of transcription, DNA-dependent
- positive regulation of humoral immune response
- positive regulation of transcription, DNA-dependent
- positive regulation of interferon-gamma production
- blastocyst formation
- positive regulation of antral ovarian follicle growth
- positive regulation of acrosome reaction
- positive regulation of ovarian follicle development
- egg coat formation
- positive regulation of type IV hypersensitivity
- positive regulation of acrosomal vesicle exocytosis
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- egg coat
- extracellular matrix
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of egg coat
- receptor agonist activity
- carbohydrate binding
- extracellular matrix structural constituent
- acrosin binding