Rtl1 Gene Summary [Mouse]
Involved in several processes, including placenta development; skeletal muscle satellite cell proliferation; and skeletal muscle tissue development. Acts upstream of or within angiogenesis and labyrinthine layer development. Is active in Z disc. Is expressed in several structures, including diaphragm; genitourinary system; immune system; musculature; and neocortex layer. Orthologous to human RTL1 (retrotransposon Gag like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtl1 |
| Official Name | retrotransposon Gaglike 1 [Source:MGI Symbol;Acc:MGI:2656842] |
| Ensembl ID | ENSMUSG00000085925 |
| Bio databases IDs | |
| Aliases | retrotransposon Gaglike 1 |
| Synonyms | 6430411K18Rik, AABR07065531.3, HUR1, LOC107987208, Mar, Mar1, MART1, Mor1, PEG11, retrotransposon Gag like 1, retrotransposon-like 1, SIRH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- Ty3 transposon capsid-like protein
- RNase H-like domain found in reverse transcriptase
- ps-ssRNAv_RdRp-like
- Serine-rich region of AP3B1, clathrin-adaptor complex
- Retrotransposon gag protein
- Cellular and retroviral pepsin-like aspartate proteases
- gag-polyprotein putative aspartyl protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- specific language impairment
- growth failure
role in cell
- expression in
- abnormal morphology
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtl1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane