RTL1 Gene Summary [Human]
This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | RTL1 |
| Official Name | retrotransposon Gag like 1 [Source:HGNC Symbol;Acc:HGNC:14665] |
| Ensembl ID | ENSG00000254656 |
| Bio databases IDs | |
| Aliases | retrotransposon Gag like 1, Sushi-Ichi retrotransposon homolog 2, mammalian retrotransposon-derived 1, paternally expressed 11 |
| Synonyms | 6430411K18Rik, AABR07065531.3, HUR1, LOC107987208, Mar, Mar1, MART1, Mor1, PEG11, retrotransposon Gag like 1, retrotransposon-like 1, SIRH2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- Ty3 transposon capsid-like protein
- RNase H-like domain found in reverse transcriptase
- ps-ssRNAv_RdRp-like
- Serine-rich region of AP3B1, clathrin-adaptor complex
- Retrotransposon gag protein
- Cellular and retroviral pepsin-like aspartate proteases
- gag-polyprotein putative aspartyl protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- specific language impairment
- growth failure
role in cell
- expression in
- abnormal morphology
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTL1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane