Igf1r Gene Summary [Mouse]
Enables insulin-like growth factor binding activity and insulin-like growth factor receptor activity. Involved in several processes, including adrenal gland development; insulin-like growth factor receptor signaling pathway; and positive regulation of metabolic process. Acts upstream of or within several processes, including exocrine pancreas development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf1r |
| Official Name | insulin-like growth factor I receptor [Source:MGI Symbol;Acc:MGI:96433] |
| Ensembl ID | ENSMUSG00000005533 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor I receptor |
| Synonyms | A330103N21RIK, CD221, D930020L01, hyft, Igf1r beta isoform, IGF-1 receptor, IGF1R β, Igf1r β isoform, IGFIR, IGFIRC, IGFR, IGFR1, IGFRb, insulin-like growth factor 1 receptor, insulin-like growth factor I receptor, Insulin-like growth factor I receptor precursor, JTK13, LOC51049, MGC18216 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igf1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- Furin-like cysteine rich region
- ATP-binding domain
- insulin-like growth factor binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- activation loop
- polypeptide hormone binding
- NPXY motif
- FU
- cytoplasmic domain
- trypsin inhibitor-like cysteine rich domain
- NPEY domain
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- cysteine rich domain
- extracellular domain
- Protein kinase (unclassified specificity)
- Growth factor receptor domain IV
- Protein tyrosine and serine/threonine kinase
- ectodomain
- Tyrosine autophosphorylation site
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- Trypsin Inhibitor like cysteine rich domain
- Receptor L domain
- binding protein
- tyrosine cluster region
- Protein Kinases, catalytic domain
- FN3
- insulin-like growth factor receptor
- transmembrane domain
- tyrosine kinase domain
- Furin-like repeats
- Furin-like repeat, cysteine-rich
- structural molecule
- transporter
Pathways
Biological processes and signaling networks where the Igf1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Cardiac Hypertrophy Signaling
- CREB Signaling in Neurons
- EIF2 Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Growth Hormone Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Huntington's Disease Signaling
- IGF-1 Signaling
- IL-15 Production
- NF-κB Signaling
- PTEN Signaling
- RhoA Signaling
- Role of NFAT in Cardiac Hypertrophy
- Sperm Motility
- STAT3 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-squamous lung carcinoma
- lung squamous cell carcinoma
- epithelial cancer
- epithelial neoplasia
- migraines
- schizophrenia
- secondary neoplasm
- breast cancer
- neoplasia
- cancer
role in cell
- survival
- migration
- expression in
- phosphorylation in
- growth
- proliferation
- activation in
- apoptosis
- production in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- plasma membrane fraction
- caveolae fraction
- membrane fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- fusion site
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cell-cell contacts
- apical membrane
- caveolae
- basolateral membrane
- nucleoli
- growth cone
- transverse tubules
- microsomal membrane
- membrane rafts
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igf1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- insulin receptor signaling pathway
- negative regulation of MAPK cascade
- cellular senescence
- positive regulation of cell proliferation
- protein autophosphorylation
- positive regulation of protein complex disassembly
- cardiac atrium development
- positive regulation of steroid hormone biosynthetic process
- positive regulation of smooth muscle cell proliferation
- cellular response to testosterone stimulus
- beta-amyloid clearance
- response to ethanol
- protein kinase B signaling cascade
- cellular response to estradiol stimulus
- positive regulation of axon regeneration
- immune response
- cellular response to progesterone stimulus
- transcytosis
- cellular response to glucose stimulus
- axonogenesis
- cellular response to zinc ion starvation
- positive regulation of kinase activity
- negative regulation of muscle cell apoptotic process
- positive regulation of cytokinesis
- positive regulation of osteoblast proliferation
- cerebellum development
- signal transduction
- response to vitamin E
- insulin-like growth factor receptor signaling pathway
- peptidyl-tyrosine autophosphorylation
- response to alkaloid
- hippocampus development
- response to nicotine
- positive regulation of MAPK cascade
- dendritic spine maintenance
- regulation of JNK cascade
- cellular response to transforming growth factor beta stimulus
- cellular response to mechanical stimulus
- negative regulation of apoptotic process
- positive regulation of DNA metabolic process
- establishment of cell polarity
- cellular response to dexamethasone stimulus
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- insulin receptor complex
- T-tubule
- caveola
- intracellular membrane-bounded organelle
- membrane
- alphav-beta3 integrin-IGF-1-IGF1R complex
- receptor complex
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- insulin binding
- identical protein binding
- insulin-like growth factor-activated receptor activity
- insulin receptor binding
- insulin-like growth factor binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- insulin-activated receptor activity
- G-protein alpha-subunit binding
- insulin receptor substrate binding
- insulin-like growth factor I binding